Journal article
Obtaining EQ-5D-5L utilities from the disease specific Quality of Life Alzheimer’s Disease Scale: Development and results from a mapping study
- Abstract:
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Purpose: The Quality of Life Alzheimer’s Disease Scale (QoL-AD) is commonly used to assess disease specific health-related quality of life (HRQoL) as rated by patients and their carers. For cost-effectiveness analyses, utilities based on the EQ-5D are often required. We report a new mapping algorithm to obtain EQ-5D indices when only QoL-AD data are available.
Methods: Different statistical models to estimate utility directly, or responses to individual EQ-5D questions (response mapping) from QoL-AD, were trialled for patient-rated and proxy-rated questionnaires. Model performance was assessed by root mean square error and mean absolute error.
Results: The response model using multinomial regression including age and sex, performed best in both the estimation dataset and an independent dataset.
Conclusions: The recommended mapping algorithm allows researchers for the first time to estimate EQ-5D values from QoL-AD data, enabling cost-utility analyses using datasets where the QoL-AD but no utility measures were collected.
- Publication status:
- Published
- Peer review status:
- Peer reviewed
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(Preview, Version of record, 986.6KB, Terms of use)
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- Publisher copy:
- 10.1007/s11136-020-02670-8
Authors
- Publisher:
- Springer
- Journal:
- Quality of Life Research More from this journal
- Volume:
- 30
- Issue:
- 2021
- Pages:
- 867–879
- Publication date:
- 2020-10-17
- Acceptance date:
- 2020-09-13
- DOI:
- EISSN:
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1573-2649
- ISSN:
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0962-9343
- Language:
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English
- Keywords:
- Pubs id:
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1133140
- Local pid:
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pubs:1133140
- Deposit date:
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2020-09-21
Terms of use
- Copyright holder:
- Rombach et al.
- Copyright date:
- 2020
- Rights statement:
- © The Author(s) 2020. This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/.
- Licence:
- CC Attribution (CC BY)
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