Prevalence of pre-eclampsia and adverse pregnancy outcomes in women with pre-existing cardiomyopathy: a multi-centre retrospective cohort study

Ormesher, L; Vause, S; Higson, S; Roberts, A; Clarke, B; Curtis, S; Ordonez, V; Ansari, F; Everett, TR; Hordern, C; Mackillop, L; Stern, V; Bonnett, T; Reid, A; Wallace, S; Oyekan, E; Douglas, H; Cauldwell, M; Reddy, M; Palmer, K; Simpson, M; Brennand, J; Minns, L; Freeman, L; Murray, S

Women's Health Collection

Journal article

Prevalence of pre-eclampsia and adverse pregnancy outcomes in women with pre-existing cardiomyopathy: a multi-centre retrospective cohort study

Abstract:: Pre-eclampsia is associated with postnatal cardiac dysfunction; however, the nature of this relationship remains uncertain. This multicentre retrospective cohort study aimed to determine the prevalence of pre-eclampsia in women with pre-existing cardiac dysfunction (left ventricular ejection fraction < 55%) and explore the relationship between pregnancy outcome and pre-pregnancy cardiac phenotype. In this cohort of 282 pregnancies, pre-eclampsia prevalence was not significantly increased (4.6% [95% C.I 2.2–7.0%] vs. population prevalence of 4.6% [95% C.I. 2.7–8.2], p = 0.99); 12/13 women had concurrent obstetric/medical risk factors for pre-eclampsia. The prevalence of preterm pre-eclampsia (< 37 weeks) and fetal growth restriction (FGR) was increased (1.8% vs. 0.7%, p = 0.03; 15.2% vs. 5.5%, p < 0.001, respectively). Neither systolic nor diastolic function correlated with pregnancy outcome. Antenatal ß blockers (n = 116) were associated with lower birthweight Z score (adjusted difference − 0.31 [95% C.I. − 0.61 to − 0.01], p = 0.04). To conclude, this study demonstrated a modest increase in preterm pre-eclampsia and significant increase in FGR in women with pre-existing cardiac dysfunction. Our results do not necessarily support a causal relationship between cardiac dysfunction and pre-eclampsia, especially given the population’s background risk status. The mechanism underpinning the relationship between cardiac dysfunction and FGR merits further research but could be influenced by concomitant ß blocker use

Publication status:: Published

Peer review status:: Peer reviewed

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APA Style

Ormesher, L., Vause, S., Higson, S., Roberts, A., Clarke, B., Curtis, S., Ordonez, V., Ansari, F., Everett, T. R., Hordern, C., Mackillop, L., Stern, V., Bonnett, T., Reid, A., Wallace, S., Oyekan, E., Douglas, H., Cauldwell, M., Reddy, M., … Murray, S. (2023). Prevalence of pre-eclampsia and adverse pregnancy outcomes in women with pre-existing cardiomyopathy: a multi-centre retrospective cohort study. Scientific Reports, 13(1), 153–153.

MLA Style

Ormesher, L, et al. “Prevalence of Pre-Eclampsia and Adverse Pregnancy Outcomes in Women with Pre-Existing Cardiomyopathy: a Multi-Centre Retrospective Cohort Study.” Scientific Reports, vol. 13, no. 1, 2023, pp. 153–53.

Chicago Style

Ormesher, L, S Vause, S Higson, et al. 2023. “Prevalence of Pre-Eclampsia and Adverse Pregnancy Outcomes in Women with Pre-Existing Cardiomyopathy: a Multi-Centre Retrospective Cohort Study.” Scientific Reports 13 (1): 153–53.
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