Journal article
Parkin-mediated ubiquitination contributes to the constitutive turnover of mitochondrial fission factor (Mff)
- Abstract:
-
The mitochondrial outer membrane protein Mitochondrial Fission Factor (Mff) plays a key role in both physiological and pathological fission. It is well established that at stressed or functionally impaired mitochondria, PINK1 recruits the ubiquitin ligase Parkin which ubiquitinates Mff and other mitochondrial outer membrane proteins to facilitate the removal of defective mitochondria and maintain the integrity of the mitochondrial network. Here we show that, in addition to this clearance path...
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- Publication status:
- Published
- Peer review status:
- Peer reviewed
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Authors
Funding
British Heart Foundation
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Bibliographic Details
- Publisher:
- Public Library of Science Publisher's website
- Journal:
- PloS One Journal website
- Volume:
- 14
- Issue:
- 5
- Article number:
- e0213116
- Place of publication:
- United States
- Publication date:
- 2019-05-21
- Acceptance date:
- 2019-05-06
- DOI:
- EISSN:
-
1932-6203
- ISSN:
-
1932-6203
- Pmid:
-
31112535
Item Description
- Language:
- English
- Keywords:
- Pubs id:
-
1159771
- Local pid:
- pubs:1159771
- Deposit date:
- 2021-02-02
Terms of use
- Copyright holder:
- Lee et al.
- Copyright date:
- 2019
- Rights statement:
- ©2019 Lee et al. This is an open access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.
- Licence:
- CC Attribution (CC BY)
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