Hepcidin is the major predictor of erythrocyte iron incorporation in anemic African children

Journal article

Iron supplementation strategies in the developing world remain controversial because of fears of exacerbating prevalent infectious diseases. Understanding the conditions in which iron will be absorbed and incorporated into erythrocytes is therefore important. We studied Gambian children with either postmalarial or nonmalarial anemia, who were given oral iron supplements daily for 30 days. Supplements administered on days 1 and 15 contained the stable iron isotopes (57)Fe and (58)Fe, respectiv...

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Authors: Prentice, A; Doherty, C; Abrams, S; Cox, S; Atkinson, S

• Publication status: Published
• Peer review status: Peer reviewed
• Publisher: American Society of Hematology Publisher's website
• Journal: Blood Journal website
• Volume: 119
• Issue: 8
• Pages: 1922-1928
• Publication date: 2012-02-23
• Acceptance date: 2011-12-22
• DOI: 10.1182/blood-2011-11-391219
• EISSN: 1528-0020
• ISSN: 0006-4971
• Pmid: 22228627
• Language: English
• Keywords: Iron, Dietary; Treatment Outcome; Journal Article; Research Support, Non-U.S. Gov't; Multivariate Analysis; Iron Isotopes; research-article; Antimicrobial Cationic Peptides; Child, Preschool; Anemia, Iron-Deficiency; Infant; C-Reactive Protein; Ferritins; Drug Administration Schedule; Clinical Trial; Enzyme-Linked Immunosorbent Assay; Antimalarials; Gambia; Research Support, U.S. Gov't, Non-P.H.S.; Hepcidins; Receptors, Transferrin; Malaria, Falciparum; Predictive Value of Tests; Time Factors; Erythrocytes; Humans; SBTMR