Journal article : Review
Cooperation and interplay between EGFR signalling and extracellular vesicle biogenesis in cancer
- Abstract:
- Epidermal growth factor receptor (EGFR) takes centre stage in carcinogenesis throughout its entire cellular trafficking odyssey. When loaded in extracellular vesicles (EVs), EGFR is one of the key proteins involved in the transfer of information between parental cancer and bystander cells in the tumour microenvironment. To hijack EVs, EGFR needs to play multiple signalling roles in the life cycle of EVs. The receptor is involved in the biogenesis of specific EV subpopulations, it signals as an active cargo, and it can influence the uptake of EVs by recipient cells. EGFR regulates its own inclusion in EVs through feedback loops during disease progression and in response to challenges such as hypoxia, epithelial-to-mesenchymal transition and drugs. Here, we highlight how the spatiotemporal rules that regulate EGFR intracellular function intersect with and influence different EV biogenesis pathways and discuss key regulatory features and interactions of this interplay. We also elaborate on outstanding questions relating to EGFR-driven EV biogenesis and available methods to explore them. This mechanistic understanding will be key to unravelling the functional consequences of direct anti-EGFR targeted and indirect EGFR-impacting cancer therapies on the secretion of pro-tumoural EVs and on their effects on drug resistance and microenvironment subversion.
- Publication status:
- Published
- Peer review status:
- Peer reviewed
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(Preview, Version of record, pdf, 1.6MB, Terms of use)
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- Publisher copy:
- 10.3390/cells9122639
Authors
- Publisher:
- MDPI
- Journal:
- Cells More from this journal
- Volume:
- 9
- Issue:
- 12
- Article number:
- 2639
- Publication date:
- 2020-12-08
- Acceptance date:
- 2020-12-02
- DOI:
- EISSN:
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2073-4409
- Pmid:
-
33302515
- Language:
-
English
- Keywords:
- Subtype:
-
Review
- Pubs id:
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1151461
- Local pid:
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pubs:1151461
- Deposit date:
-
2021-02-10
- ARK identifier:
Terms of use
- Copyright holder:
- LC Zanetti-Domingues et al.
- Copyright date:
- 2020
- Rights statement:
- © 2020 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/).
- Licence:
- CC Attribution (CC BY)
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