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Maple syrup decreases TDP-43 proteotoxicity in a caenorhabditis elegans model of amyotrophic lateral sclerosis (ALS)

Abstract:

Amyotrophic lateral sclerosis (ALS) is a neurodegenerative disease causing death of the motor neurons. Proteotoxicity caused by TDP-43 protein is an important aspect of ALS pathogenesis, with TDP-43 being the main constituent of the aggregates found in patients. We have previously tested the effect of different sugars on the proteotoxicity caused by the expression of mutant TDP-43 in Caenorhabditis elegans. Here we tested maple syrup, a natural compound containing many active molecules includ...

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Publication status:
Published
Peer review status:
Peer reviewed

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Publisher copy:
10.1021/acs.jafc.5b05432

Authors


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Institution:
University of Oxford
Division:
Medical Sciences Division
Department:
Psychiatry
Oxford college:
Green Templeton College
Parker, JA More by this author
Therrien, M More by this author
CHUM Foundation More from this funder
ALS Society of Canada More from this funder
Canadian Institutes of Health Research More from this funder
Fonds de Recherche Sante Quebec More from this funder
Muscular Dystrophy Association More from this funder
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Publisher:
American Chemical Society Publisher's website
Journal:
Journal of Agricultural and Food Chemistry Journal website
Volume:
64
Issue:
17
Pages:
3338–3344
Publication date:
2016-04-13
Acceptance date:
2016-04-13
DOI:
EISSN:
1520-5118
ISSN:
0021-8561
Pubs id:
pubs:930658
URN:
uri:3f2bbdc4-46f8-4a48-8e00-9cb9b289bbfd
UUID:
uuid:3f2bbdc4-46f8-4a48-8e00-9cb9b289bbfd
Local pid:
pubs:930658

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