Journal article
The clock gene Bmal1 inhibits macrophage motility, phagocytosis, and impairs defense against pneumonia
- Abstract:
-
The circadian clock regulates many aspects of immunity. Bacterial infections are affected by time of day, but the mechanisms involved remain undefined. Here we show that loss of the core clock protein BMAL1 in macrophages confers protection against pneumococcal pneumonia. Infected mice show both reduced weight loss and lower bacterial burden in circulating blood. In vivo studies of macrophage phagocytosis reveal increased bacterial ingestion following Bmal1 deletion, which was also seen in vi...
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- Publication status:
- Published
- Peer review status:
- Peer reviewed
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Authors
Bibliographic Details
- Publisher:
- National Academy of Sciences Publisher's website
- Journal:
- Proceedings of the National Academy of Sciences Journal website
- Volume:
- 117
- Issue:
- 3
- Pages:
- 1543-1551
- Publication date:
- 2020-01-03
- Acceptance date:
- 2019-12-19
- DOI:
- EISSN:
-
1091-6490
- ISSN:
-
0027-8424
- Pmid:
-
31900362
Item Description
- Language:
- English
- Keywords:
- Pubs id:
-
pubs:1081313
- UUID:
-
uuid:3f25675b-293f-48ce-842b-65f9d38f4b9c
- Local pid:
- pubs:1081313
- Source identifiers:
-
1081313
- Deposit date:
- 2020-01-10
Terms of use
- Copyright holder:
- Kitchen et al.
- Copyright date:
- 2020
- Rights statement:
- © 2020 the Author(s). Published by PNAS. This open access article is distributed under Creative Commons Attribution License 4.0 (CC BY)
- Licence:
- CC Attribution (CC BY)
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