Journal article
A three-antigen Plasmodium falciparum DNA prime—Adenovirus boost malaria vaccine regimen is superior to a two-antigen regimen and protects against controlled human malaria infection in healthy malaria-naïve adults
- Abstract:
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Background
A DNA-prime/human adenovirus serotype 5 (HuAd5) boost vaccine encoding Plasmodium falciparum (Pf) circumsporozoite protein (PfCSP) and Pf apical membrane antigen-1 (PfAMA1), elicited protection in 4/15 (27%) of subjects against controlled human malaria infection (CHMI) that was statistically associated with CD8+ T cell responses. Subjects with high level pre-existing immunity to HuAd5 were not protected, suggesting an adverse effect on vaccine efficacy (VE).... Expand abstract
- Publication status:
- Published
- Peer review status:
- Peer reviewed
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(Preview, Version of record, 2.8MB, Terms of use)
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- Publisher copy:
- 10.1371/journal.pone.0256980
Authors
- Publisher:
- Public Library of Science
- Journal:
- PLoS One More from this journal
- Volume:
- 16
- Issue:
- 9
- Article number:
- e0256980
- Publication date:
- 2021-09-08
- Acceptance date:
- 2021-08-15
- DOI:
- EISSN:
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1932-6203
- Language:
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English
- Keywords:
- Pubs id:
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1191851
- Local pid:
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pubs:1191851
- Deposit date:
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2021-08-22
Terms of use
- Copyright date:
- 2021
- Rights statement:
- Copyright: This is an open access article, free of all copyright, and may be freely reproduced, distributed, transmitted, modified, built upon, or otherwise used by anyone for any lawful purpose. The work is made available under the Creative Commons CC0 public domain dedication.
- Licence:
- CC Public Domain Dedication (CC0)
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