Journal article : Comment
Top-down and bottom-up neuroscience: overcoming the clash of research cultures
- Abstract:
- As scientists, we want solid answers, but we also want to answer questions that matter. Yet, the brain’s complexity forces trade-offs between these desiderata, bringing about two distinct research approaches in neuroscience that we describe as ‘top-down’ and ‘bottom-up’. Recognizing the validity of both approaches dispels misunderstandings and unnecessary tension and promotes constructive interactions.
- Publication status:
- Published
- Peer review status:
- Reviewed (other)
Actions
Access Document
- Files:
-
-
(Preview, Accepted manuscript, pdf, 208.3KB, Terms of use)
-
- Publisher copy:
- 10.1038/s41583-025-00946-x
Authors
+ Wellcome Trust
More from this funder
- Funder identifier:
- https://ror.org/029chgv08
- Funding agency for:
- Luppi, AI
- Grant:
- 226924/Z/23/Z
- Programme:
- Early Career Award
+ National Institute of Mental Health
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- Funder identifier:
- https://ror.org/04t0s7x83
- Funding agency for:
- Pessoa, L
- Grant:
- MH071589
+ Danish National Research Foundation
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- Funder identifier:
- https://ror.org/00znyv691
- Funding agency for:
- Kringelbach, ML
- Programme:
- Center for Music in the Brain
+ Carlsberg Foundation
More from this funder
- Funder identifier:
- https://ror.org/01kpjmx04
- Funding agency for:
- Kringelbach, ML
- Programme:
- Centre for Eudaimonia and Human Flourishing
+ NIHR Maudsley Biomedical Research Centre
More from this funder
- Funder identifier:
- https://ror.org/05fd9ct06
- Funding agency for:
- Turkheimer, F
- Publisher:
- Springer Nature
- Journal:
- Nature Reviews Neuroscience More from this journal
- Volume:
- 26
- Issue:
- 9
- Pages:
- 513–515
- Place of publication:
- England
- Publication date:
- 2025-07-21
- DOI:
- EISSN:
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1471-0048
- ISSN:
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1471-003X
- Pmid:
-
40696003
- Language:
-
English
- Subtype:
-
Comment
- Pubs id:
-
2248801
- Local pid:
-
pubs:2248801
- Deposit date:
-
2025-12-19
- ARK identifier:
Terms of use
- Copyright holder:
- Springer Nature Limited
- Copyright date:
- 2025
- Rights statement:
- © 2025, Springer Nature Limited.
- Notes:
- The author accepted manuscript (AAM) of this paper has been made available under the University of Oxford's Open Access Publications Policy, and a CC BY public copyright licence has been applied.
- Licence:
- CC Attribution (CC BY)
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