Retinoic acid as a novel medical therapy for Cushing's disease in dogs.

Journal article

Cushing's disease is almost always caused by an ACTH-secreting pituitary tumor, but effective medical therapy is currently limited. Because retinoic acid has been shown to be potentially useful in decreasing corticotroph secretion and proliferation in rodent models, we have studied its action in dogs with Cushing's disease. A randomized treatment with retinoic acid (n = 22) vs. ketoconazole (n = 20) in dogs with Cushing's disease was assigned for a period of 180 d. Clinical signs, plasma ACTH...

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Authors: Castillo, V; Giacomini, D; Páez-Pereda, M; Stalla, J; Labeur, M

• Publication status: Published
• Journal: Endocrinology
• Volume: 147
• Issue: 9
• Pages: 4438-4444
• Publication date: 2006-09-01
• DOI: 10.1210/en.2006-0414
• EISSN: 1945-7170
• ISSN: 0013-7227
• Language: English
• Keywords: Tretinoin; Survival Rate; Ketoconazole; Pituitary ACTH Hypersecretion; Creatinine; Animals; Hydrocortisone; Dogs; Adrenocorticotropic Hormone; Pituitary Gland; Male; Dog Diseases; Magnetic Resonance Imaging; Body Weight; Pituitary Neoplasms; Adenoma; Female; alpha-MSH