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Parallel retention of Pdx2 genes in cartilaginous fish and coelacanths.

Abstract:

The Pdx1 or Ipf1 gene encodes an important homeodomain-containing protein with key roles in pancreas development and function. Mutations in human PDX1 are implicated in developmental defects and disease of the pancreas. Extensive research, including genome sequencing, has indicated that Pdx1 is the only member of its gene family in mammals, birds, amphibians, and ray-finned fish, and with the exception of teleost fish, this gene forms part of the ParaHox ge...

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Publication status:
Published
Peer review status:
Peer reviewed
Version:
Publisher's version

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Publisher copy:
10.1093/molbev/msq121

Authors


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Institution:
University of Oxford
Department:
Oxford, MPLS, Zoology
Holland, PW More by this author
Publisher:
Oxford University Press Publisher's website
Journal:
Molecular biology and evolution Journal website
Volume:
27
Issue:
10
Pages:
2386-2391
Publication date:
2010-10-05
DOI:
EISSN:
1537-1719
ISSN:
0737-4038
URN:
uuid:3ed93360-594f-40f7-bc6c-0a6bc2e41643
Source identifiers:
204460
Local pid:
pubs:204460

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