- Abstract:
-
Comprehensive analysis of the gene expression profiles associated with human monocyte-to-macrophage differentiation and polarization toward M1 or M2 phenotypes led to the following main results: 1) M-CSF-driven monocyte-to-macrophage differentiation is associated with activation of cell cycle genes, substantiating the underestimated proliferation potential of monocytes. 2) M-CSF leads to expression of a substantial part of the M2 transcriptome, suggesting that under homeostatic conditions a d...
Expand abstract - Publication status:
- Published
- Publisher copy:
- 10.4049/jimmunol.177.10.7303
-
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- Journal:
- Journal of immunology (Baltimore, Md. : 1950)
- Volume:
- 177
- Issue:
- 10
- Pages:
- 7303-7311
- Publication date:
- 2006-11-05
- DOI:
- EISSN:
-
1550-6606
- ISSN:
-
0022-1767
- URN:
-
uuid:3ecbc349-b637-44f6-82a4-7dd7c467c10d
- Source identifiers:
-
21736
- Local pid:
- pubs:21736
- Language:
- English
- Keywords:
- Copyright date:
- 2006
Journal article
Transcriptional profiling of the human monocyte-to-macrophage differentiation and polarization: new molecules and patterns of gene expression.
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