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Transcriptional profiling of the human monocyte-to-macrophage differentiation and polarization: new molecules and patterns of gene expression.

Abstract:

Comprehensive analysis of the gene expression profiles associated with human monocyte-to-macrophage differentiation and polarization toward M1 or M2 phenotypes led to the following main results: 1) M-CSF-driven monocyte-to-macrophage differentiation is associated with activation of cell cycle genes, substantiating the underestimated proliferation potential of monocytes. 2) M-CSF leads to expression of a substantial part of the M2 transcriptome, suggesting that under homeostatic conditions a d...

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Publication status:
Published

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Authors


Martinez, FO More by this author
More by this author
Institution:
University of Oxford
Department:
Oxford, MSD, Pathology Dunn School
Mantovani, A More by this author
Journal:
Journal of immunology (Baltimore, Md. : 1950)
Volume:
177
Issue:
10
Pages:
7303-7311
Publication date:
2006-11-05
DOI:
EISSN:
1550-6606
ISSN:
0022-1767
URN:
uuid:3ecbc349-b637-44f6-82a4-7dd7c467c10d
Source identifiers:
21736
Local pid:
pubs:21736

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