- Abstract:
-
Background
Expand abstract
Dose-finding trials are essential to drug development as they establish recommended doses for later-phase testing. We aim to motivate wider use of model-based designs for dose-finding, such as the continual reassessment method (CRM).
Methods
We carried out a literature review of dose-finding designs and conducted a survey to identify perceived barriers to their implementation.
Results
We describe the benefits of model-based designs (flexibility,... - Publication status:
- Published
- Peer review status:
- Peer reviewed
- Version:
- Publisher's version
- Files:
-
-
(pdf, 500.3kb)
-
- Publisher copy:
- 10.1038/bjc.2017.186
-
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- Publisher:
- Springer Nature Publisher's website
- Journal:
- British Journal of Cancer Journal website
- Volume:
- 117
- Issue:
- 3
- Pages:
- 332–339
- Publication date:
- 2017-06-29
- Acceptance date:
- 2017-05-04
- DOI:
- EISSN:
-
1532-1827
- ISSN:
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0007-0920
- Pubs id:
-
pubs:695680
- URN:
-
uri:3ec3ed37-67a6-4ed8-8384-41d091d28508
- UUID:
-
uuid:3ec3ed37-67a6-4ed8-8384-41d091d28508
- Local pid:
- pubs:695680
- Keywords:
- Copyright holder:
- Love et al.
- Copyright date:
- 2017
- Notes:
-
Copyright © 2017 Love et al. This work is licensed under the Creative Commons Attribution 4.0 International License.
To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/
Journal article
Embracing model-based designs for dose-finding trials
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