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Embracing model-based designs for dose-finding trials

Abstract:

Background
Dose-finding trials are essential to drug development as they establish recommended doses for later-phase testing. We aim to motivate wider use of model-based designs for dose-finding, such as the continual reassessment method (CRM).

Methods
We carried out a literature review of dose-finding designs and conducted a survey to identify perceived barriers to their implementation.

Results
We describe the benefits of model-based designs (flexibility,...

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Publication status:
Published
Peer review status:
Peer reviewed

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Publisher copy:
10.1038/bjc.2017.186

Authors


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Institution:
University of Oxford
Division:
MSD
Department:
NDORMS
Sub department:
Centre for Statistics in Medicine
Role:
Author
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More from this funder
Funding agency for:
Love, S
Grant:
C5529/A16895
Publisher:
Springer Nature Publisher's website
Journal:
British Journal of Cancer Journal website
Volume:
117
Issue:
3
Pages:
332–339
Publication date:
2017-06-29
Acceptance date:
2017-05-04
DOI:
EISSN:
1532-1827
ISSN:
0007-0920
Keywords:
Pubs id:
pubs:695680
UUID:
uuid:3ec3ed37-67a6-4ed8-8384-41d091d28508
Local pid:
pubs:695680
Deposit date:
2017-05-18

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