Embracing model-based designs for dose-finding trials
Dose-finding trials are essential to drug development as they establish recommended doses for later-phase testing. We aim to motivate wider use of model-based designs for dose-finding, such as the continual reassessment method (CRM).
We carried out a literature review of dose-finding designs and conducted a survey to identify perceived barriers to their implementation.
We describe the benefits of model-based designs (flexibility,...
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- Love et al
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