Journal article
Characterizing mutational signatures in human cancer cell lines reveals episodic APOBEC mutagenesis
- Abstract:
-
Multiple signatures of somatic mutations have been identified in cancer genomes. Exome sequences of 1,001 human cancer cell lines and 577 xenografts revealed most common mutational signatures, indicating past activity of the underlying processes, usually in appropriate cancer types. To investigate ongoing patterns of mutational-signature generation, cell lines were cultured for extended periods and subsequently DNA sequenced. Signatures of discontinued exposures, including tobacco smoke and u...
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- Publication status:
- Published
- Peer review status:
- Peer reviewed
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Authors
Bibliographic Details
- Publisher:
- Cell Press Publisher's website
- Journal:
- Cell Journal website
- Volume:
- 176
- Issue:
- 6
- Pages:
- 1282-1294
- Publication date:
- 2019-03-07
- Acceptance date:
- 2019-01-27
- DOI:
- EISSN:
-
1097-4172
- ISSN:
-
0092-8674
- Pmid:
-
30849372
Item Description
- Language:
- English
- Keywords:
- Pubs id:
-
pubs:982824
- UUID:
-
uuid:3eaa87d5-6c57-4896-b643-4db448745563
- Local pid:
- pubs:982824
- Source identifiers:
-
982824
- Deposit date:
- 2019-04-05
Terms of use
- Copyright holder:
- Crown
- Copyright date:
- 2019
- Notes:
- Crown Copyright © 2019. Published by Elsevier Inc.. This is an open access article under the CC BY license.
- Licence:
- CC Attribution (CC BY)
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