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Journal article

VCAM-1 targeted magnetic resonance imaging enables detection of brain micrometastases from different primary tumours

Abstract:

Purpose: A major issue for the effective treatment of brain metastasis is the late stage of diagnosis with existing clinical tools. The aim of this study was to evaluate the potential of vascular cell adhesion molecule-1 (VCAM-1) targeted magnetic resonance imaging (MRI) for early detection of brain micrometastases in mouse models across multiple primary tumour types. Experimental Design: Xenograft models of brain micrometastasis for human breast carcinoma (MDA231Br-GFP), lung adenocarcinoma ...

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Publication status:
Published
Peer review status:
Peer reviewed

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Publisher copy:
10.1158/1078-0432.CCR-18-1889

Authors


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Institution:
University of Oxford
Division:
Medical Sciences Division
Department:
Oncology
Sub department:
CRUK/MRC Ox Inst Radiation Oncology
Role:
Author
More by this author
Institution:
University of Oxford
Division:
Medical Sciences Division
Department:
Oncology
Sub department:
CRUK/MRC Ox Inst Radiation Oncology
Role:
Author
More by this author
Institution:
University of Oxford
Division:
Medical Sciences Division
Department:
Oncology
Sub department:
CRUK/MRC Ox Inst Radiation Oncology
Role:
Author
More by this author
Institution:
University of Oxford
Division:
Medical Sciences Division
Department:
Oncology
Sub department:
CRUK/MRC Ox Inst Radiation Oncology
Role:
Author
More from this funder
Funding agency for:
Soto, M
Khrapitchev, A
Balderas, F
Sibson, N
Grant:
C5255/A15935
C5255/A15935
C5255/A15935
C5255/A15935
More from this funder
Funding agency for:
Cheng, VWT
Grant:
Clinical research fellowship
Publisher:
American Association for Cancer Research
Journal:
Clinical Cancer Research More from this journal
Volume:
25
Issue:
2
Publication date:
2018-11-02
Acceptance date:
2018-10-30
DOI:
EISSN:
1557-3265
ISSN:
1078-0432
Keywords:
Pubs id:
pubs:937120
UUID:
uuid:3eaa73a4-cc50-4f95-9034-f7dbaf31fbdb
Local pid:
pubs:937120
Source identifiers:
937120
Deposit date:
2018-11-05

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