Conference item
Structural and thermodynamic characterization of the gating pathway in a K+ channel
- Abstract:
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Structures of inwardly-rectifying (Kir) potassium channels are now available in many different crystallographic states. We now analyse these structures in the context of functional data for mutations at over 180 positions within the Kir1.1 (ROMK) channel. This reveals an extensive network of physically interacting residues which stabilise the pre-open and open-states of the channel, but which breaks down upon channel closure. This approach not only validates a structural gating pathway for th...
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- Publication status:
- Published
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- Publisher copy:
- 10.1016/j.bpj.2013.11.888
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Bibliographic Details
- Publisher:
- Elsevier Publisher's website
- Volume:
- 106
- Issue:
- 2
- Pages:
- 155A-155A
- Host title:
- Biophysical Journal
- Publication date:
- 2014-01-28
- DOI:
- ISSN:
-
0006-3495
- Source identifiers:
-
476153
Item Description
- Keywords:
- Pubs id:
-
pubs:476153
- UUID:
-
uuid:3e75dd44-3de1-4c5a-83ca-beccc8be45b8
- Local pid:
- pubs:476153
- Deposit date:
- 2014-07-24
Terms of use
- Copyright holder:
- Biophysical Society
- Copyright date:
- 2014
- Notes:
- © 2014 Biophysical Society. Published by Elsevier Inc. All rights reserved.
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