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Structural and thermodynamic characterization of the gating pathway in a K+ channel

Abstract:

Structures of inwardly-rectifying (Kir) potassium channels are now available in many different crystallographic states. We now analyse these structures in the context of functional data for mutations at over 180 positions within the Kir1.1 (ROMK) channel. This reveals an extensive network of physically interacting residues which stabilise the pre-open and open-states of the channel, but which breaks down upon channel closure. This approach not only validates a structural gating pathway for th...

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Publication status:
Published

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Publisher copy:
10.1016/j.bpj.2013.11.888

Authors


Bollepalli, MK More by this author
Fowler, PW More by this author
Rapedius, M More by this author
Sansom, MSP More by this author
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Publisher:
Elsevier Publisher's website
Volume:
106
Issue:
2
Pages:
155A-155A
Publication date:
2014-01-28
DOI:
ISSN:
0006-3495
URN:
uuid:3e75dd44-3de1-4c5a-83ca-beccc8be45b8
Source identifiers:
476153
Local pid:
pubs:476153

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