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Journal article

The influence of insulin resistance on CSF and plasma biomarkers of Alzheimer’s pathology

Abstract:

Background: Insulin resistance (IR) has previously been associated with an increased risk of developing Alzheimer’s disease (AD), though the relationship between IR and AD is not yet clear. Here, we examined the influence of IR on AD by using plasma and cerebrospinal fluid (CSF) biomarkers related to IR and AD in cognitively healthy men, and to characterize the shared protein signatures between IR and AD.

Methods: 58 cognitively healthy men, 28 IR and 30 non-IR (age and APOE ε4 mat...

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Publication status:
Published
Peer review status:
Peer reviewed

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Publisher copy:
10.1186/s13195-017-0258-6

Authors


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Institution:
University of Oxford
Division:
MSD
Department:
Psychiatry
Role:
Author
More by this author
Institution:
University of Oxford
Division:
MSD
Department:
Psychiatry
Role:
Author
More by this author
Institution:
University of Oxford
Division:
MSD
Department:
Psychiatry
Role:
Author
More by this author
Institution:
University of Oxford
Division:
MSD
Department:
Psychiatry
Role:
Author
More by this author
Institution:
University of Oxford
Division:
MSD
Department:
Psychiatry
Role:
Author
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More from this funder
Grant:
FP7/2007-2013) Innovative Medicines Initiative Joint Undertaking
Publisher:
BioMed Central Publisher's website
Journal:
Alzheimer's Research and Therapy Journal website
Volume:
9
Issue:
31
Publication date:
2017-04-26
Acceptance date:
2017-03-08
DOI:
ISSN:
1758-9193
Source identifiers:
685186
Keywords:
Pubs id:
pubs:685186
UUID:
uuid:3e62ff06-a305-4eae-ade4-fdf203557dd1
Local pid:
pubs:685186
Deposit date:
2017-03-09

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