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Increased cortical neuronal responses to NMDA and improved attentional set-shifting performance in rats following prebiotic (B-GOS®) ingestion

Abstract:

We have previously shown that prebiotics (dietary fibres that augment the growth of indigenous beneficial gut bacteria) such as BimunoTM galacto-oligosaccharides (B-GOS®), increased N-methyl-D-aspartate (NMDA) receptor levels in the rat brain. The current investigation examined the functional correlates of these changes in B-GOS®-fed rats by measuring cortical neuronal responses to NMDA using in vivo NMDA micro-iontophoresis electrophysiology, and performance in the attentional set-shifting t...

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Publication status:
Published
Peer review status:
Peer reviewed
Version:
Publisher's version

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Publisher copy:
10.1016/j.euroneuro.2017.11.001

Authors


Gronier, B More by this author
Savignac, HM More by this author
Di Meceli, M More by this author
Idriss, SM More by this author
Tzortzis, G More by this author
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Grant:
Industrial Partnership Award (Principal Investigator, Dr Burnet; Grant Code: BB/I006311/1)
Clasado Biosciences Ltd More from this funder
Publisher:
Elsevier Publisher's website
Journal:
European Neuropsychopharmacology Journal website
Volume:
28
Issue:
1
Pages:
211-224
Publication date:
2017-11-22
Acceptance date:
2017-11-02
DOI:
ISSN:
0924-977X
Pubs id:
pubs:742558
URN:
uri:3e4df25b-1aa4-4c33-acb7-e5f8279b2b50
UUID:
uuid:3e4df25b-1aa4-4c33-acb7-e5f8279b2b50
Local pid:
pubs:742558

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