Journal article
Neuroscience of apathy and anhedonia: a transdiagnostic approach
- Abstract:
- Apathy and anhedonia are common syndromes of motivation that are associated with a wide range of brain disorders and have no established therapies. Research using animal models suggests that a useful framework for understanding motivated behaviour lies in effort-based decision making for reward. The neurobiological mechanisms underpinning such decisions have now begun to be determined in individuals with apathy or anhedonia, providing an important foundation for developing new treatments. The findings suggest that there might be some shared mechanisms between both syndromes. A transdiagnostic approach that cuts across traditional disease boundaries provides a potentially useful means for understanding these conditions.
- Publication status:
- Published
- Peer review status:
- Peer reviewed
Actions
Access Document
- Files:
-
-
(Preview, Accepted manuscript, pdf, 1.2MB, Terms of use)
-
- Publisher copy:
- 10.1038/s41583-018-0029-9
Authors
- Publisher:
- Springer Nature
- Journal:
- Nature Reviews Neuroscience More from this journal
- Volume:
- 19
- Pages:
- 470–484
- Publication date:
- 2018-06-26
- Acceptance date:
- 2018-03-23
- DOI:
- EISSN:
-
1471-0048
- ISSN:
-
1471-003X
- Pubs id:
-
pubs:834412
- UUID:
-
uuid:3e481f87-0ede-47dd-bdd8-2db78dfd3694
- Local pid:
-
pubs:834412
- Source identifiers:
-
834412
- Deposit date:
-
2018-04-08
Terms of use
- Copyright holder:
- Macmillan Publishers Limited, part of Springer Nature
- Copyright date:
- 2018
- Notes:
- Copyright © 2018 Macmillan Publishers Limited, part of Springer Nature. This is the accepted manuscript version of the article. The final version is available online from Springer Nature at: https://doi.org/10.1038/s41583-018-0029-9
If you are the owner of this record, you can report an update to it here: Report update to this record