Journal article icon

Journal article

Type 9 secretion system structures reveal a new protein transport mechanism

Abstract:

The type 9 secretion system (T9SS) is the protein export pathway of bacteria of the Gram-negative Fibrobacteres–Chlorobi–Bacteroidetes superphylum and is an essential determinant of pathogenicity in severe periodontal disease. The central element of the T9SS is a so-far uncharacterized protein-conducting translocon located in the bacterial outer membrane. Here, using cryo-electron microscopy, we provide structural evidence that the translocon is the T9SS protein SprA. SprA forms an extremely ...

Expand abstract
Publication status:
Published
Peer review status:
Peer reviewed
Version:
Accepted Manuscript

Actions


Access Document


Files:
Publisher copy:
10.1038/s41586-018-0693-y

Authors


More by this author
Institution:
University of Oxford
Division:
Medical Sciences Division
Department:
Biochemistry
More by this author
Institution:
University of Oxford
Division:
Medical Sciences Division
Department:
Pathology Dunn School
More by this author
Institution:
University of Oxford
Division:
Medical Sciences Division
Department:
Pathology Dunn School
More by this author
Institution:
University of Oxford
Division:
Medical Sciences Division
Department:
Biochemistry
Oxford college:
Wadham College
ORCID:
0000-0001-9685-4067
More from this funder
Grant:
Investigator Award 107929/Z/15/Z
Investigator Award 100298/Z/12/Z
Publisher:
Springer Nature Publisher's website
Journal:
Nature Journal website
Volume:
564
Pages:
77–82
Publication date:
2018-11-07
Acceptance date:
2018-09-13
DOI:
EISSN:
1476-4687
ISSN:
0028-0836
Pubs id:
pubs:920031
URN:
uri:3e2f9244-f0f8-42b6-a4c2-f01d3c7c5740
UUID:
uuid:3e2f9244-f0f8-42b6-a4c2-f01d3c7c5740
Local pid:
pubs:920031

Terms of use


Metrics



If you are the owner of this record, you can report an update to it here: Report update to this record

TO TOP