- Abstract:
-
Hepatocellular carcinoma (HCC) and cirrhosis are important causes of mortality worldwide. Persistent hepatitis B virus (HBV) infection is a major cause of these diseases. Double mutations in the basal core promoter (BCP) (A1762T and G1764A) and precore (pre-C) (G1896A) regions of the virus are associated with progression to HCC. The current study is aimed at developing a simple method for screening and detecting BCP and pre-C mutations in HBV carriers. We have developed and validated an oligo...
Expand abstract - Publication status:
- Published
- Publisher copy:
- 10.1128/jcm.01622-07
-
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- Journal:
- Journal of clinical microbiology
- Volume:
- 46
- Issue:
- 8
- Pages:
- 2723-2730
- Publication date:
- 2008-08-05
- DOI:
- EISSN:
-
1098-660X
- ISSN:
-
0095-1137
- URN:
-
uuid:3e135ef1-7cb5-46b2-9be8-d21177e52d00
- Source identifiers:
-
176626
- Local pid:
- pubs:176626
- Copyright date:
- 2008
Journal article
Application of a novel, rapid, and sensitive oligonucleotide ligation assay for detection of cancer-predicting mutations in the precore and basal core promoter of hepatitis B virus.
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