Journal article icon

Journal article

Application of a novel, rapid, and sensitive oligonucleotide ligation assay for detection of cancer-predicting mutations in the precore and basal core promoter of hepatitis B virus.

Abstract:

Hepatocellular carcinoma (HCC) and cirrhosis are important causes of mortality worldwide. Persistent hepatitis B virus (HBV) infection is a major cause of these diseases. Double mutations in the basal core promoter (BCP) (A1762T and G1764A) and precore (pre-C) (G1896A) regions of the virus are associated with progression to HCC. The current study is aimed at developing a simple method for screening and detecting BCP and pre-C mutations in HBV carriers. We have developed and validated an oligo...

Expand abstract
Publication status:
Published

Actions


Access Document


Publisher copy:
10.1128/jcm.01622-07

Authors


Le Roux, E More by this author
Jeng-Barry, A More by this author
Expand authors...
Journal:
Journal of clinical microbiology
Volume:
46
Issue:
8
Pages:
2723-2730
Publication date:
2008-08-05
DOI:
EISSN:
1098-660X
ISSN:
0095-1137
URN:
uuid:3e135ef1-7cb5-46b2-9be8-d21177e52d00
Source identifiers:
176626
Local pid:
pubs:176626

Terms of use


Metrics



If you are the owner of this record, you can report an update to it here: Report update to this record

TO TOP