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First field efficacy trial of the ChAd63 MVA ME-TRAP vectored malaria vaccine candidate in 5-17 months old infants and children

Abstract:
Background Heterologous prime boost immunization with chimpanzee adenovirus 63 (ChAd63) and Modified Vaccinia Virus Ankara (MVA) vectored vaccines is a strategy previously shown to provide substantial protective efficacy against P. falciparum infection in United Kingdom adult Phase IIa sporozoite challenge studies (approximately 20–25% sterile protection with similar numbers showing clear delay in time to patency), and greater point efficacy in a trial in Kenyan adults.
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Publication status:
Published
Peer review status:
Peer reviewed
Version:
Publisher's Version

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Publisher copy:
10.1371/journal.pone.0208328

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Institution:
University of Oxford
Division:
Medical Sciences Division
Department:
NDM
Subgroup:
Jenner Institute
Coulibaly, AS More by this author
More by this author
Institution:
University of Oxford
Division:
Medical Sciences Division
Department:
NDM
Subgroup:
Jenner Institute
Oxford college:
St Cross College
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European and Developing Countries Clinical Trials Partnership More from this funder
Swedish International Development Cooperation Agency More from this funder
Austrian Federal Ministry of Science and Research More from this funder
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Publisher:
Public Library of Science Publisher's website
Journal:
PLoS ONE Journal website
Volume:
13
Issue:
12
Pages:
Article: e0208328
Publication date:
2018-12-12
Acceptance date:
2018-11-28
DOI:
EISSN:
1932-6203
Pubs id:
pubs:946705
URN:
uri:3e122f64-005d-40af-ac89-dafc684ae498
UUID:
uuid:3e122f64-005d-40af-ac89-dafc684ae498
Local pid:
pubs:946705

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