Journal article
First field efficacy trial of the ChAd63 MVA ME-TRAP vectored malaria vaccine candidate in 5-17 months old infants and children
- Abstract:
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Background Heterologous prime boost immunization with chimpanzee adenovirus 63 (ChAd63) and Modified Vaccinia Virus Ankara (MVA) vectored vaccines is a strategy previously shown to provide substantial protective efficacy against P. falciparum infection in United Kingdom adult Phase IIa sporozoite challenge studies (approximately 20–25% sterile protection with similar numbers showing clear delay in time to patency), and greater point efficacy in a trial in Kenyan adults.
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- Publication status:
- Published
- Peer review status:
- Peer reviewed
- Version:
- Publisher's Version
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- Files:
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(pdf, 2.5MB)
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- Publisher copy:
- 10.1371/journal.pone.0208328
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Authors
Funding
European and Developing Countries Clinical Trials Partnership
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Swedish International Development Cooperation Agency
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Austrian Federal Ministry of Science and Research
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Irish Aid
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Bibliographic Details
- Publisher:
- Public Library of Science Publisher's website
- Journal:
- PLoS ONE Journal website
- Volume:
- 13
- Issue:
- 12
- Pages:
- Article: e0208328
- Publication date:
- 2018-12-12
- Acceptance date:
- 2018-11-28
- DOI:
- EISSN:
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1932-6203
- Pubs id:
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pubs:946705
- URN:
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uri:3e122f64-005d-40af-ac89-dafc684ae498
- UUID:
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uuid:3e122f64-005d-40af-ac89-dafc684ae498
- Local pid:
- pubs:946705
Terms of use
- Copyright holder:
- Tiono et al.
- Copyright date:
- 2018
- Notes:
- © 2018 Tiono et al. This is an open access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.
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