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Fusion pore in exocytosis: more than an exit gate? A β-cell perspective

Abstract:

Secretory vesicle exocytosis is a fundamental biological event and the process by which hormones (like insulin) are released into the blood. Considerable progress has been made in understanding this precisely orchestrated sequence of events from secretory vesicle docked at the cell membrane, hemifusion, to the opening of a membrane fusion pore. The exact biophysical and physiological regulation of these events implies a close interaction between membrane proteins and lipids in a confined spac...

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Publication status:
Published
Peer review status:
Peer reviewed
Version:
Accepted Manuscript

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Publisher copy:
10.1016/j.ceca.2017.10.005

Authors


More by this author
Institution:
University of Oxford
Division:
Medical Sciences Division
Department:
RDM
Subgroup:
OCDEM
Role:
Author
ORCID:
0000-0003-1244-7857
More by this author
Institution:
University of Oxford
Division:
Medical Sciences Division
Department:
RDM
Subgroup:
OCDEM
Role:
Author
More by this author
Institution:
University of Oxford
Division:
Medical Sciences Division
Department:
RDM
Subgroup:
RDM Strategic
Oxford college:
Harris Manchester College
Role:
Author
ORCID:
0000-0001-7578-0767
More by this author
Role:
Author
ORCID:
0000-0001-6847-5641
Publisher:
Elsevier Publisher's website
Journal:
Cell Calcium Journal website
Volume:
68
Pages:
45-61
Publication date:
2017-11-02
Acceptance date:
2017-10-24
DOI:
EISSN:
1532-1991
ISSN:
0143-4160
Pubs id:
pubs:746133
URN:
uri:3e10edf0-b038-45e2-bb4d-4d61141c0c6b
UUID:
uuid:3e10edf0-b038-45e2-bb4d-4d61141c0c6b
Local pid:
pubs:746133

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