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Genome-wide association study in 79,366 European-ancestry individuals informs the genetic architecture of 25-hydroxyvitamin D levels.

Abstract:

Vitamin D is a steroid hormone precursor that is associated with a range of human traits and diseases. Previous GWAS of serum 25-hydroxyvitamin D concentrations have identified four genome-wide significant loci (GC, NADSYN1/DHCR7, CYP2R1, CYP24A1). In this study, we expand the previous SUNLIGHT Consortium GWAS discovery sample size from 16,125 to 79,366 (all European descent). This larger GWAS yields two additional loci harboring genome-wide significant variants (P = 4.7×10-9 at rs8018720 in ...

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Publication status:
Published
Peer review status:
Peer reviewed
Version:
Publisher's version

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Publisher copy:
10.1038/s41467-017-02662-2

Authors


O'Reilly, PF More by this author
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ORCID:
0000-0003-0907-2548
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ORCID:
0000-0002-3746-9086
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Publisher:
Nature Publishing Group Publisher's website
Journal:
Nature Communications Journal website
Volume:
9
Issue:
1
Pages:
260
Publication date:
2017-01-05
Acceptance date:
2017-12-15
DOI:
EISSN:
2041-1723
Pubs id:
pubs:820891
URN:
uri:3e0746a1-2628-4ccc-8dd6-ca050eac5836
UUID:
uuid:3e0746a1-2628-4ccc-8dd6-ca050eac5836
Local pid:
pubs:820891
Language:
English
Keywords:

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