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The consequences of mitochondrial amyloid beta-peptide in Alzheimer's disease.

Abstract:

The Abeta (amyloid-beta peptide) has long been associated with Alzheimer's disease, originally in the form of extracellular plaques. However, in the present paper we review the growing evidence for the role of soluble intracellular Abeta in the disease progression, with particular reference to Abeta found within the mitochondria. Once inside the cell, Abeta is able to interact with a number of targets, including the mitochondrial proteins ABAD (amyloid-binding alcohol dehydrogenase) and CypD ...

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Publication status:
Published

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Publisher copy:
10.1042/bj20091941

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Institution:
University of Oxford
Department:
Oxford, MPLS, Chemistry, Organic Chemistry
Role:
Author
Journal:
The Biochemical journal
Volume:
426
Issue:
3
Pages:
255-270
Publication date:
2010-03-05
DOI:
EISSN:
1470-8728
ISSN:
0264-6021
URN:
uuid:3dfadb4f-4097-4c2b-a70e-34d74a5b5d86
Source identifiers:
52018
Local pid:
pubs:52018

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