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Activated regulatory T-cells, dysfunctional and senescent T-cells hinder the immunity in pancreatic cancer

Abstract:

Pancreatic cancer has one of the worst prognoses of any human malignancy and leukocyte infiltration is a major prognostic marker of the disease. As current immunotherapies confer negligible survival benefits, there is a need to better characterise leukocytes in pancreatic cancer to identify better therapeutic strategies. In this study, we analysed 32 human pancreatic cancer patients from two independent cohorts. A multi-parameter mass-cytometry analysis was performed on 32,000 T-cells from ei...

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Publication status:
Published
Peer review status:
Peer reviewed

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Files:
Publisher copy:
10.3390/cancers13081776

Authors


Publisher:
MDPI Publisher's website
Journal:
Cancers Journal website
Volume:
13
Issue:
8
Article number:
1776
Publication date:
2021-04-08
Acceptance date:
2021-03-29
DOI:
EISSN:
2072-6694
Language:
English
Keywords:
Pubs id:
1170900
Local pid:
pubs:1170900
Deposit date:
2021-04-12

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