Journal article
Hepatitis A virus capsid structure
- Abstract:
- Hepatitis A virus (HAV) has been enigmatic, evading detailed structural analysis for many years. Its recently determined high-resolution structure revealed an angular surface without the indentations often characteristic of receptor-binding sites. The viral protein 1 (VP1) β-barrel shows no sign of a pocket factor and the amino terminus of VP2 displays a “domain swap” across the pentamer interface, as in a subset of mammalian picornaviruses and insect picorna-like viruses. Structure-based phylogeny confirms this placement. These differences suggest an uncoating mechanism distinct from that of enteroviruses. An empty capsid structure reveals internal differences in VP0 and the VP1 amino terminus connected with particle maturation. An HAV/Fab complex structure, in which the antigen-binding fragment (Fab) appears to act as a receptor–mimic, clarifies some historical epitope mapping data, but some remain difficult to reconcile. We still have little idea of the structural features of enveloped HAV particles.
- Publication status:
- Published
- Peer review status:
- Peer reviewed
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(Accepted manuscript, tiff, 1.8MB, Terms of use)
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- Publisher copy:
- 10.1101/cshperspect.a031807
Authors
- Publisher:
- Cold Spring Harbor Labaratory Press
- Journal:
- Cold Spring Harbor Perspectives in Medicine More from this journal
- Volume:
- 9
- Issue:
- 5
- Article number:
- a031807doi
- Publication date:
- 2018-07-23
- Acceptance date:
- 2018-04-12
- DOI:
- EISSN:
-
2157-1422
- Pmid:
-
30037986
- Language:
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English
- Pubs id:
-
pubs:891344
- UUID:
-
uuid:3df4f2c8-0107-483b-b70f-7359f97e9b82
- Local pid:
-
pubs:891344
- Source identifiers:
-
891344
- Deposit date:
-
2019-02-22
- ARK identifier:
Terms of use
- Copyright holder:
- Cold Spring Harbor Labaratory Press
- Copyright date:
- 2018
- Notes:
- Copyright © 2018 Cold Spring Harbor Laboratory Press. This is the accepted manuscript version of the article. The final version is available online from Cold Spring Harbor Laboratory Press at: https://doi.org/10.1101/cshperspect.a031807
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