Dissociations within short-term memory in GluA1 AMPA receptor subunit knockout mice.

Journal article

GluA1 AMPA receptor subunit knockout mice display a selective impairment on short-term recognition memory tasks. In this study we tested whether GluA1 is important for short-term memory that is necessary for bridging the discontiguity between cues in trace conditioning. GluA1 knockout mice were not impaired at using short-term memory traces of T-maze floor inserts, made of different materials, to bridge the temporal gap between conditioned stimuli and reinforcement during appetitive discrimination tasks. Thus, different aspects of short-term memory are differentially sensitive to GluA1 deletion. This dissociation may reflect processing of qualitatively different short-term memory traces. Memory that results in performance of short-term recognition (e.g. for objects or places) may be different from the memory required for associative learning in trace conditioning.

Authors: Taylor, A; Niewoehner, B; Seeburg, P; Sprengel, R; Rawlins, J

• Publication status: Published
• Journal: Behavioural brain research
• Volume: 224
• Issue: 1
• Pages: 8-14
• Publication date: 2011-10-01
• DOI: 10.1016/j.bbr.2011.05.016
• EISSN: 1872-7549
• ISSN: 0166-4328
• Language: English
• Keywords: Discrimination (Psychology); Maze Learning; Conditioning (Psychology); Cues; Memory, Short-Term; Mice; Disease Models, Animal; Association Learning; Space Perception; Receptors, AMPA; Animals; Female; Memory Disorders; Mice, Knockout