- Abstract:
-
Recent clinical trials have used CXCR4 antagonists for the rapid mobilization of CD34(+) haemopoietic stem/progenitor cells (HSC/HPC) from the bone marrow to the blood in patients refractory to granulocyte-colony-stimulating factor (G-CSF). These antagonists not only mobilize non-cycling cells with a higher proportion of repopulating cells, but also enhance CD34(+) cell mobilization when used in combination with G-CSF. Here, we review the importance of CXCR4 and its ligand CXCL12 in haemopoie...
Expand abstract - Publication status:
- Published
- Publisher copy:
- 10.1111/j.1423-0410.2007.00995.x
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- Journal:
- Vox sanguinis
- Volume:
- 94
- Issue:
- 1
- Pages:
- 18-32
- Publication date:
- 2008-01-05
- DOI:
- EISSN:
-
1423-0410
- ISSN:
-
0042-9007
- URN:
-
uuid:3ddfd5e1-a188-4bdb-918a-b359c5d017f1
- Source identifiers:
-
348774
- Local pid:
- pubs:348774
- Language:
- English
- Keywords:
- Copyright date:
- 2008
Journal article
The central role of the chemokine receptor, CXCR4, in haemopoietic stem cell transplantation: will CXCR4 antagonists contribute to the treatment of blood disorders?
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