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The central role of the chemokine receptor, CXCR4, in haemopoietic stem cell transplantation: will CXCR4 antagonists contribute to the treatment of blood disorders?

Abstract:

Recent clinical trials have used CXCR4 antagonists for the rapid mobilization of CD34(+) haemopoietic stem/progenitor cells (HSC/HPC) from the bone marrow to the blood in patients refractory to granulocyte-colony-stimulating factor (G-CSF). These antagonists not only mobilize non-cycling cells with a higher proportion of repopulating cells, but also enhance CD34(+) cell mobilization when used in combination with G-CSF. Here, we review the importance of CXCR4 and its ligand CXCL12 in haemopoie...

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Publication status:
Published

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Journal:
Vox sanguinis
Volume:
94
Issue:
1
Pages:
18-32
Publication date:
2008-01-05
DOI:
EISSN:
1423-0410
ISSN:
0042-9007
URN:
uuid:3ddfd5e1-a188-4bdb-918a-b359c5d017f1
Source identifiers:
348774
Local pid:
pubs:348774

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