Identification of the regions of the HPV 5 E6 protein involved in Bak degradation and inhibition of apoptosis.

Journal article

UVB induced DNA damage is the major aetiological agent in NMSC development, but mounting evidence suggests a role for human papillomaviruses (HPV) from genus beta, including HPV 5 and HPV 8, in the development of NMSC on sun exposed body sites. We have previously shown that UVB activates Bak, an apoptogenic mitochondrial factor that, following an apoptotic stimulus, undergoes a conformational change that leads to pore formation in the mitochondrial membrane that releases apoptotic factors. Th...

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Authors: Simmonds, M; Storey, A

• Publication status: Published
• Journal: International journal of cancer. Journal international du cancer
• Volume: 123
• Issue: 10
• Pages: 2260-2266
• Publication date: 2008-11-01
• DOI: 10.1002/ijc.23815
• EISSN: 1097-0215
• ISSN: 0020-7136
• Language: English
• Keywords: bcl-2 Homologous Antagonist-Killer Protein; Oncogene Proteins, Viral; Flow Cytometry; Cell Line; Hydrolysis; Humans; Point Mutation; Animals; Blotting, Western; Apoptosis