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Protein aggregate-ligand binding assays based on microfluidic diffusional separation

Abstract:

The measurement of molecular interactions with pathological protein aggregates, including amyloid fibrils, is of central importance in the context of the development of diagnostic and therapeutic strategies against protein misfolding disorders. Probing such interactions by conventional methods can, however, be challenging because of the supramolecular nature of protein aggregates, their heterogeneity, and their often dynamic nature. Here we demonstrate that direct measurement of diffusion on ...

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Publication status:
Published
Peer review status:
Peer reviewed
Version:
Accepted Manuscript

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Publisher copy:
10.1002/cbic.201600384

Authors


Müller, T More by this author
De Genst, E More by this author
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Department:
Oxford, MPLS, Chemistry, Physical & Theoretical Chem
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Funding agency for:
Benesch, J
Publisher:
Wiley-VCH Verlag Publisher's website
Journal:
ChemBioChem Journal website
Volume:
17
Issue:
20
Pages:
1920-1924
Publication date:
2016-07-29
DOI:
EISSN:
1439-7633
ISSN:
1439-4227
Pubs id:
pubs:640790
URN:
uri:3db31f19-be45-40f6-ae3b-006b3251c881
UUID:
uuid:3db31f19-be45-40f6-ae3b-006b3251c881
Local pid:
pubs:640790

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