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Myeloid and lymphoid contribution to non-haematopoietic lineages through irradiation-induced heterotypic cell fusion.

Abstract:

Recent studies have suggested that regeneration of non-haematopoietic cell lineages can occur through heterotypic cell fusion with haematopoietic cells of the myeloid lineage. Here we show that lymphocytes also form heterotypic-fusion hybrids with cardiomyocytes, skeletal muscle, hepatocytes and Purkinje neurons. However, through lineage fate-mapping we demonstrate that such in vivo fusion of lymphoid and myeloid blood cells does not occur to an appreciable extent in steady-state adult tissue...

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Publication status:
Published

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Publisher copy:
10.1038/ncb1721

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Journal:
Nature cell biology
Volume:
10
Issue:
5
Pages:
584-592
Publication date:
2008-05-01
DOI:
EISSN:
1476-4679
ISSN:
1465-7392
Source identifiers:
246532

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