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Prevalence of serum neutralizing antibodies against chimpanzee adenovirus 63 and human adenovirus 5 in Kenyan children, in the context of vaccine vector efficacy.

Abstract:

Vaccination against Plasmodium falciparum malaria could reduce the worldwide burden of this disease, and decrease its high mortality in children. Replication-defective recombinant adenovirus vectors carrying P. falciparum epitopes may be useful as part of a vaccine that raises cellular immunity to the pre-erythrocytic stage of malaria infection. However, existing immunity to the adenovirus vector results in antibody-mediated neutralization of the vaccine vector, and reduced vaccine immunogeni...

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Publication status:
Published

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Authors


Dudareva, M More by this author
Andrews, L More by this author
More by this author
Institution:
University of Oxford
Department:
Oxford, MSD, Clinical Medicine, Jenner Institute
More by this author
Institution:
University of Oxford
Department:
Oxford, MSD, Clinical Medicine, Jenner Institute
More by this author
Institution:
University of Oxford
Department:
Oxford, MSD, Clinical Medicine, Tropical Medicine
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Journal:
Vaccine
Volume:
27
Issue:
27
Pages:
3501-3504
Publication date:
2009-06-05
DOI:
EISSN:
1873-2518
ISSN:
0264-410X
URN:
uuid:3da925b5-8a32-4bf7-86bc-44d7069972e1
Source identifiers:
41217
Local pid:
pubs:41217

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