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Journal article

BRCA2-dependent and independent formation of RAD51 nuclear foci.

Abstract:

The formation of RAD51 foci in response to ionizing radiation (IR) represents an important step in the repair of DNA double-strand breaks. RAD51 foci also appear during S phase and are thought to be required for the restart of stalled or broken replication forks. The RAD51 recombinase interacts directly with the breast cancer-associated tumour suppressor BRCA2, an interaction that is required for normal recombination proficiency, radiation resistance and genome stability. In CAPAN-1 cells, wh...

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Publication status:
Published

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Publisher copy:
10.1038/sj.onc.1206263

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Institution:
University of Oxford
Department:
Oxford, MSD, Oncology
Journal:
Oncogene
Volume:
22
Issue:
8
Pages:
1115-1123
Publication date:
2003-02-05
DOI:
EISSN:
1476-5594
ISSN:
0950-9232
URN:
uuid:3d6bb0e6-a6d6-4c71-8f4f-78bd29c9d994
Source identifiers:
131343
Local pid:
pubs:131343

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