2-Aminobenzaldehydes as versatile substrates for rhodium-catalyzed alkyne hydroacylation: application to dihydroquinolone synthesis.

Journal article

Amine for it! A cationic rhodium catalyst, which was assembled insitu from commercial components, promoted the reaction of a range of simple 2-aminobenzaldehydes with terminal and internal alkynes in a series of intermolecular hydroacylation reactions. The products of this reaction, amino-substituted enones, were efficiently converted into the corresponding dihydro-4-quinolones. © 2013 The Authors. Published by Wiley-VCH Verlag GmbH and Co. KGaA. This is an open access article under the terms of the Creative Commons Attribution License, which permits use, distribution and reproduction in any medium, provided the original work is properly cited.

Authors: Castaing, M; Wason, S; Estepa, B; Hooper, J; Willis, M

• Publication status: Published
• Journal: Angewandte Chemie (International ed. in English)
• Volume: 52
• Issue: 50
• Pages: 13280-13283
• Publication date: 2013-12-01
• DOI: 10.1002/anie.201308127
• EISSN: 1521-3773
• ISSN: 1433-7851
• Language: English
• Keywords: dihydroquinolones; enones; amines; rhodium catalysis; aldehydes