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Modelling toehold-mediated RNA strand displacement.

Abstract:

We study the thermodynamics and kinetics of an RNA toehold-mediated strand displacement reaction with a recently developed coarse-grained model of RNA. Strand displacement, during which a single strand displaces a different strand previously bound to a complementary substrate strand, is an essential mechanism in active nucleic acid nanotechnology and has also been hypothesized to occur in vivo. We study the rate of displacement reactions as a function of the length of the toehold and temperat...

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Publication status:
Published
Peer review status:
Peer reviewed

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Publisher copy:
10.1016/j.bpj.2015.01.023

Authors


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Institution:
University of Oxford
Division:
MPLS
Department:
Physics
Sub department:
Theoretical Physics
Role:
Author
More by this author
Institution:
University of Oxford
Division:
MPLS
Department:
Chemistry
Sub department:
Physical & Theoretical Chem
Role:
Author
More by this author
Institution:
University of Oxford
Division:
MPLS
Department:
Chemistry
Sub department:
Physical & Theoretical Chem
Role:
Author
More by this author
Institution:
University of Oxford
Division:
MPLS
Department:
Physics
Sub department:
Theoretical Physics
Role:
Author
More from this funder
Funding agency for:
Ouldridge, T
Engineering and Physical Sciences Research Council More from this funder
University College, Oxford More from this funder
Publisher:
Cell Press Publisher's website
Journal:
Biophysical journal Journal website
Volume:
108
Issue:
5
Pages:
1238-1247
Publication date:
2015-03-01
DOI:
EISSN:
1542-0086
ISSN:
0006-3495
Source identifiers:
490973
Language:
English
Keywords:
Pubs id:
pubs:490973
UUID:
uuid:3d606bca-c491-4ada-af54-8b41f1236204
Local pid:
pubs:490973
Deposit date:
2014-11-22

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