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Involvement of the N-terminus of Kir6.2 in the inhibition of the KATP channel by ATP.

Abstract:

1. ATP-sensitive potassium (KATP) channels are composed of pore-forming Kir6.2 and regulatory SUR subunits. A truncated isoform of Kir6.2, Kir6.2DeltaC26, expresses ATP-sensitive channels in the absence of SUR1, suggesting the ATP-inhibitory site lies on the Kir6. 2 subunit. 2. We examined the effect on the channel ATP sensitivity of mutating the arginine residue at position 50 (R50) in the N-terminus of Kir6.2, by recording macroscopic currents in membrane patches excised from Xenopus oocyte...

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Publication status:
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Institution:
University of Oxford
Division:
MPLS
Department:
Physics
Sub department:
Condensed Matter Physics
Role:
Author
More by this author
Institution:
University of Oxford
Division:
MSD
Department:
Physiology Anatomy & Genetics
Role:
Author
Journal:
Journal of physiology
Volume:
514 ( Pt 1)
Issue:
1
Pages:
19-25
Publication date:
1999-01-01
DOI:
EISSN:
1469-7793
ISSN:
0022-3751
Source identifiers:
15880
Language:
English
Keywords:
Pubs id:
pubs:15880
UUID:
uuid:3d45d836-69a7-48c1-873c-dc9cdb6e06e1
Local pid:
pubs:15880
Deposit date:
2012-12-19

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