Journal article
Chronic kidney disease and incident cancer risk: an individual participant data meta-analysis
- Abstract:
-
BackgroundStudies examining the association of chronic kidney disease (CKD) with cancer risk have demonstrated conflicting results.MethodsThis was an individual participant data meta-analysis including 54 international cohorts contributing to the CKD Prognosis Consortium. Included cohorts had data on albuminuria [urine albumin-to-creatinine ratio (ACR)], estimated glomerular filtration rate (eGFR), overall and site-specific cancer incidence, and established risk factors for cancer. Included participants were aged 18 years or older, without previous cancer or kidney failure.ResultsAmong 1,319,308 individuals, the incidence rate of overall cancer was 17.3 per 1000 person-years. Higher ACR was positively associated with cancer risk [adjusted hazard ratio 1.08 (95% CI 1.06–1.10) per 8-fold increase in ACR]. No association of eGFR with overall cancer risk was seen. For site-specific cancers, lower eGFR was associated with urological cancer and multiple myeloma, whereas higher ACR was associated with many cancer types (kidney, head/neck, colorectal, liver, pancreas, bile duct, stomach, larynx, lung, hemolymphatic, leukaemia, and multiple myeloma). Results were similar in a 1-year landmark analysis.DiscussionAlbuminuria, but not necessarily eGFR, was independently associated with the subsequent risk of cancer. Our results warrant an investigation into mechanisms that explain the link between albuminuria and cancer.
- Publication status:
- Published
- Peer review status:
- Peer reviewed
Actions
Access Document
- Files:
-
-
(Preview, Version of record, pdf, 980.8KB, Terms of use)
-
(Preview, Supplementary materials, pdf, 417.1KB, Terms of use)
-
- Publisher copy:
- 10.1038/s41416-025-03140-z
Authors
+ Wellcome Trust
More from this funder
- Funder identifier:
- https://ror.org/029chgv08
- Grant:
- 301005/Z/23/Z
- Publisher:
- Springer Nature
- Journal:
- British Journal of Cancer More from this journal
- Publication date:
- 2025-09-06
- Acceptance date:
- 2025-07-21
- DOI:
- EISSN:
-
1532-1827
- ISSN:
-
0007-0920
- Language:
-
English
- Pubs id:
-
2256598
- Local pid:
-
pubs:2256598
- Deposit date:
-
2025-07-30
Terms of use
- Copyright holder:
- Mok et al
- Copyright date:
- 2025
- Rights statement:
- © The Author(s) 2025. This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder.
- Licence:
- CC Attribution (CC BY)
If you are the owner of this record, you can report an update to it here: Report update to this record