- Abstract:
-
A series of substituted 3-(4-nitrophenyloxy)methylindole-4,7-diones (Q) were synthesised. The effects of substitution patterns on the indole core on rates of elimination of 4-nitrophenol as a model for drug release following fragmentation of a phenolic ether linker were studied. After reduction to either the radical anion (Q·-) or hydroquinone (QH2) elimination of 4-nitrophenol occurred from the (indol-3-yl)methyl position. The half-lives of Q·- radicals at [O2] ≈ 5 μmol dm-3, typical of tumo...
Expand abstract - Publication status:
- Published
- Publisher copy:
- 10.1039/b009652k
-
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- Journal:
- JOURNAL OF THE CHEMICAL SOCIETY-PERKIN TRANSACTIONS 2
- Issue:
- 5
- Pages:
- 843-860
- Publication date:
- 2001
- DOI:
- EISSN:
-
1364-5471
- ISSN:
-
1472-779X
- URN:
-
uuid:3d1ddd7a-a6dd-47d0-9c75-37dedecad673
- Source identifiers:
-
131521
- Local pid:
- pubs:131521
- Language:
- English
- Copyright date:
- 2001
Journal article
Controlling the rates of reductively-activated elimination from the (indol-3-yl)methyl position of indolequinones
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