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Efficacy of the MMP inhibitor MMI270 against lung metastasis following removal of orthotopically transplanted human colon cancer in rat.

Abstract:

We have investigated the antitumor effects of synthetic MMP inhibitor MMI270 against postoperative lung metastasis from colon cancer in nude rat. The KM12SM human colon cancer cells were injected into the cecal wall, and at 5 weeks after the injection, the cecum was removed including the tumor. Then, 30 mg/kg of MMI270 was administered perorally twice per day for 2 or 4 weeks, either immediately after removal or after week 2 after the removal. At week 7 after the removal, lung metastasis was ...

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Publication status:
Published

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Publisher copy:
10.1002/ijc.21285

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Journal:
International journal of cancer. Journal international du cancer
Volume:
118
Issue:
1
Pages:
215-221
Publication date:
2006-01-05
DOI:
EISSN:
1097-0215
ISSN:
0020-7136
URN:
uuid:3d119db6-e939-4c70-8c81-d8bbdfddf3eb
Source identifiers:
226436
Local pid:
pubs:226436

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