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Journal article

Human T-follicular helper and T-follicular regulatory cell maintenance is independent of germinal centers.

Abstract:

The monoclonal anti-CD20 antibody rituximab (RTX) depletes B cells in the treatment of lymphoma and autoimmune disease, and contributes to alloantibody reduction in transplantation across immunologic barriers. The effects of RTX on T cells are less well described. T-follicular helper (Tfh) cells provide growth and differentiation signals to germinal center (GC) B cells to support antibody production, and suppressive T-follicular regulatory (Tfr) cells regulate this response. In mice, both Tfh...

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Publication status:
Published

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Institution:
University of Oxford
Division:
MSD
Department:
Surgical Sciences
Role:
Author
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Journal:
Blood
Volume:
124
Issue:
17
Pages:
2666-2674
Publication date:
2014-10-01
DOI:
EISSN:
1528-0020
ISSN:
0006-4971
Source identifiers:
484289

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