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An essential role for Prox1 in the induction of the lymphatic endothelial cell phenotype.

Abstract:

The process of angiogenesis has been well documented, but little is known about the biology of lymphatic endothelial cells and the molecular mechanisms controlling lymphangiogenesis. The homeobox gene Prox1 is expressed in a subpopulation of endothelial cells that, after budding from veins, gives rise to the mammalian lymphatic system. In Prox1(-)(/-) embryos, this budding becomes arrested at around embryonic day (E)11.5, resulting in embryos without lymphatic vasculature. Unlike the endothel...

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Publication status:
Published

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Publisher copy:
10.1093/emboj/21.7.1505

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Journal:
EMBO journal
Volume:
21
Issue:
7
Pages:
1505-1513
Publication date:
2002-04-01
DOI:
EISSN:
1460-2075
ISSN:
0261-4189
Source identifiers:
102759

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