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Transmission of single HIV-1 genomes and dynamics of early immune escape revealed by ultra-deep sequencing.

Abstract:

We used ultra-deep sequencing to obtain tens of thousands of HIV-1 sequences from regions targeted by CD8+ T lymphocytes from longitudinal samples from three acutely infected subjects, and modeled viral evolution during the critical first weeks of infection. Previous studies suggested that a single virus established productive infection, but these conclusions were tempered because of limited sampling; now, we have greatly increased our confidence in this observation through modeling the obser...

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Publication status:
Published
Peer review status:
Peer reviewed

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Publisher copy:
10.1371/journal.pone.0012303

Authors


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Los Alamos National Laboratory More from this funder
Publisher:
Public Library of Science Publisher's website
Journal:
PloS one Journal website
Volume:
5
Issue:
8
Pages:
e12303
Publication date:
2010-01-01
DOI:
EISSN:
1932-6203
ISSN:
1932-6203
Source identifiers:
71144
Language:
English
Keywords:
UUID:
uuid:3d0509b8-587a-4bd3-ac2a-970d0180944c
Local pid:
pubs:71144
Deposit date:
2012-12-19

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