Transmission of single HIV-1 genomes and dynamics of early immune escape revealed by ultra-deep sequencing.
We used ultra-deep sequencing to obtain tens of thousands of HIV-1 sequences from regions targeted by CD8+ T lymphocytes from longitudinal samples from three acutely infected subjects, and modeled viral evolution during the critical first weeks of infection. Previous studies suggested that a single virus established productive infection, but these conclusions were tempered because of limited sampling; now, we have greatly increased our confidence in this observation through modeling the obser...Expand abstract
- Publication status:
- Peer review status:
- Peer reviewed
(Version of record, pdf, 2.0MB)
- Publisher copy:
- Copyright holder:
- Fischer et al
- Copyright date:
- Copyright 2010 Fischer et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.
- CC Attribution (CC BY)
If you are the owner of this record, you can report an update to it here: Report update to this record