Invasion by Toxoplasma gondii establishes a moving junction that selectively excludes host cell plasma membrane proteins on the basis of their membrane anchoring.

Journal article

The protozoan parasite Toxoplasma gondii actively penetrates its host cell by squeezing through a moving junction that forms between the host cell plasma membrane and the parasite. During invasion, this junction selectively controls internalization of host cell plasma membrane components into the parasite-containing vacuole. Membrane lipids flowed past the junction, as shown by the presence of the glycosphingolipid G(M1) and the cationic lipid label 1. 1'-dihexadecyl-3-3'-3-3'-tetramethylindo...

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Authors: Mordue, D; Desai, N; Dustin, M; Sibley, L

• Journal: Journal of experimental medicine
• Volume: 190
• Issue: 12
• Pages: 1783-1792
• Publication date: 1999-12-01
• DOI: 10.1084/jem.190.12.1783
• EISSN: 1540-9538
• ISSN: 0022-1007
• Language: English
• Keywords: Intercellular Adhesion Molecule-1; Membrane Lipids; Animals; Transfection; Toxoplasmosis; Cell Membrane; Membrane Proteins; Toxoplasma; Phagocytosis