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Studies of immunity and bacterial invasiveness in mice given a recombinant salmonella vector encoding murine interleukin-6.

Abstract:

Interleukin-6 (IL-6) was expressed in Salmonella typhimurium in an attempt to increase the mucosal immune response against the bacterium. Murine IL-6 was PCR amplified from cDNA, cloned, sequenced, and found to be functionally active when expressed in S. typhimurium BRD509, the (delta)aroA (delta)aroD vaccine strain. Expression of murine IL-6 did not appear to adversely affect the growth of salmonellae, as the construct was retained in the absence of antibiotic selection and the growth rate w...

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Publication status:
Published

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Institution:
University of Oxford
Department:
Oxford, MSD, Clinical Medicine, Tropical Medicine, Viet Nam
Ramsay, AJ More by this author
Strugnell, RA More by this author
Journal:
Infection and immunity
Volume:
64
Issue:
7
Pages:
2730-2736
Publication date:
1996-07-05
EISSN:
1098-5522
ISSN:
0019-9567
URN:
uuid:3cff89e5-989e-4dce-accf-2cd9df73f977
Source identifiers:
35946
Local pid:
pubs:35946

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