Journal article icon

Journal article

A novel compound ARN-3236 inhibits salt-inducible kinase 2 and sensitizes ovarian cancer cell lines and xenografts to paclitaxel.

Abstract:

Purpose

Salt-inducible kinase 2 (SIK2) is a centrosome kinase required for mitotic spindle formation and a potential target for ovarian cancer therapy. Here, we examine the effects of a novel small-molecule SIK2 inhibitor, ARN-3236, on sensitivity to paclitaxel in ovarian cancer.

Experimental Design

Expand abstract
Publication status:
Published
Peer review status:
Peer reviewed

Actions


Access Document


Authors


Expand authors...
Cancer Prevention and Research Institute of Texas More from this funder
Zarrow Foundation More from this funder
Mossy Foundation More from this funder
Expand funders...
Publisher:
American Association for Cancer Research Publisher's website
Journal:
Clinical Cancer Research Journal website
Volume:
23
Issue:
8
Pages:
1945-1954
Publication date:
2016-09-05
Acceptance date:
2016-09-14
DOI:
EISSN:
1557-3265
ISSN:
1078-0432
Pubs id:
pubs:647637
URN:
uri:3cf62849-680a-426f-8817-e3328f9c1512
UUID:
uuid:3cf62849-680a-426f-8817-e3328f9c1512
Local pid:
pubs:647637

Terms of use


Metrics


Views and Downloads






If you are the owner of this record, you can report an update to it here: Report update to this record

TO TOP