An exploration of regulatory T cells in transplantation: cell therapy development and immune monitoring

Thesis

Regulatory T cells (Tregs) are powerful modulators of immune function, and are of increasing interest as an adoptive cellular therapy for the treatment of transplant rejection. In a number of early clinical trials, polyclonal Treg therapy has demonstrated efficacy in maintaining graft function. However, optimal Treg immunotherapy should employ alloantigen-reactive, rather than polyclonally-reactive Tregs to ensure specificity against transplant alloresponses. In the first part of this stud...

Expand abstract

Authors: Alzhrani, AI

• Type of award: DPhil
• Level of award: Doctoral
• Awarding institution: University of Oxford
• Language: English
• Subjects: Cellular therapy