Journal article icon

Journal article

Very stable mismatch duplexes: structural and thermodynamic studies on tandem G.A mismatches in DNA.

Abstract:

We have used ultraviolet melting techniques to compare the stability of several DNA duplexes containing tandem G.A mismatches to similar duplexes containing tandem A.G, I.A, and T.A base pairs. We have found that tandem G.A mismatches in 5'-Y-G-A-R-3' duplexes are more stable than their I.A counterparts and that they are sometimes more stable than tandem 5'-Y-T-A-R-3' sequences. This is not the case for tandem G.A mismatches in other base stacking environments, and it suggests that tandem G.A...

Expand abstract
Publication status:
Published

Actions


Access Document


Publisher copy:
10.1021/bi00163a017

Authors


More by this author
Institution:
University of Oxford
Department:
Oxford, MPLS, Chemistry, Organic Chemistry
Journal:
Biochemistry
Volume:
31
Issue:
48
Pages:
12083-12086
Publication date:
1992-12-05
DOI:
EISSN:
1520-4995
ISSN:
0006-2960
URN:
uuid:3cd503c6-5bc7-4a8e-bf65-9dfbe83878c8
Source identifiers:
400089
Local pid:
pubs:400089

Terms of use


Metrics



If you are the owner of this record, you can report an update to it here: Report update to this record

TO TOP