Journal article
Identification of distinct molecular phenotypes in acute megakaryoblastic leukemia by gene expression profiling.
- Abstract:
-
Individuals with Down syndrome (DS) are predisposed to develop acute megakaryoblastic leukemia (AMKL), characterized by expression of truncated GATA1 transcription factor protein (GATA1s) due to somatic mutation. The treatment outcome for DS-AMKL is more favorable than for AMKL in non-DS patients. To gain insight into gene expression differences in AMKL, we compared 24 DS and 39 non-DS AMKL samples. We found that non-DS-AMKL samples cluster in two groups, characterized by differences in expre...
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- Publication status:
- Published
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- Publisher copy:
- 10.1073/pnas.0511150103
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Bibliographic Details
- Journal:
- Proceedings of the National Academy of Sciences of the United States of America
- Volume:
- 103
- Issue:
- 9
- Pages:
- 3339-3344
- Publication date:
- 2006-02-05
- DOI:
- EISSN:
-
1091-6490
- ISSN:
-
0027-8424
- URN:
-
uuid:3cc97832-745a-4271-8b4b-135b203dbde6
- Source identifiers:
-
39867
- Local pid:
- pubs:39867
Item Description
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- Copyright date:
- 2006
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