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Journal article

Identification of distinct molecular phenotypes in acute megakaryoblastic leukemia by gene expression profiling.

Abstract:

Individuals with Down syndrome (DS) are predisposed to develop acute megakaryoblastic leukemia (AMKL), characterized by expression of truncated GATA1 transcription factor protein (GATA1s) due to somatic mutation. The treatment outcome for DS-AMKL is more favorable than for AMKL in non-DS patients. To gain insight into gene expression differences in AMKL, we compared 24 DS and 39 non-DS AMKL samples. We found that non-DS-AMKL samples cluster in two groups, characterized by differences in expre...

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Publication status:
Published

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Publisher copy:
10.1073/pnas.0511150103

Authors


Bourquin, JP More by this author
Subramanian, A More by this author
Langebrake, C More by this author
Reinhardt, D More by this author
Bernard, O More by this author
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Journal:
Proceedings of the National Academy of Sciences of the United States of America
Volume:
103
Issue:
9
Pages:
3339-3344
Publication date:
2006-02-05
DOI:
EISSN:
1091-6490
ISSN:
0027-8424
URN:
uuid:3cc97832-745a-4271-8b4b-135b203dbde6
Source identifiers:
39867
Local pid:
pubs:39867

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