Journal article
Accelerating evidence generation: addressing critical challenges and charting a path forward
- Abstract:
- Efficient evidence generation to assess the clinical and economic impact of medical therapies is critical amid rising healthcare costs and aging populations. However, drug development and clinical trials remain far too expensive and inefficient for all stakeholders. On October 25–26, 2023, the Duke Clinical Research Institute brought together leaders from academia, industry, government agencies, patient advocacy, and nonprofit organizations to explore how different entities and influencers in drug development and healthcare can realign incentive structures to efficiently accelerate evidence generation that addresses the highest public health needs. Prominent themes surfaced, including competing research priorities and incentives, inadequate representation of patient population in clinical trials, opportunities to better leverage existing technology and infrastructure in trial design, and a need for heightened transparency and accountability in research practices. The group determined that together these elements contribute to an inefficient and costly clinical research enterprise, amplifying disparities in population health and sustaining gaps in evidence that impede advancements in equitable healthcare delivery and outcomes. The goal of addressing the identified challenges is to ultimately make clinical trials faster, more inclusive, and more efficient across diverse communities and settings.
- Publication status:
- Published
- Peer review status:
- Peer reviewed
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(Preview, Version of record, pdf, 429.5KB, Terms of use)
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- Publisher copy:
- 10.1017/cts.2024.621
Authors
- Publisher:
- Cambridge University Press
- Journal:
- Journal of Clinical and Translational Science More from this journal
- Volume:
- 8
- Issue:
- 1
- Article number:
- e184
- Publication date:
- 2024-10-31
- Acceptance date:
- 2024-09-16
- DOI:
- EISSN:
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2059-8661
- Language:
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English
- Keywords:
- Pubs id:
-
2030507
- Local pid:
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pubs:2030507
- Deposit date:
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2024-09-17
- ARK identifier:
Terms of use
- Copyright holder:
- Rim et al
- Copyright date:
- 2024
- Rights statement:
- © The Author(s), 2024. Published by Cambridge University Press on behalf of Association for Clinical and Translational Science. This is an Open Access article, distributed under the terms of the Creative Commons Attribution-NonCommercial-NoDerivatives licence (http://creativecommons.org/licenses/by-nc-nd/4.0), which permits non-commercial re-use, distribution, and reproduction in any medium, provided that no alterations are made and the original article is properly cited. The written permission of Cambridge University Press must be obtained prior to any commercial use and/or adaptation of the article.
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